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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight reduction in addition to a reduced-calorie diet and exercising.

Using two separate drugs to lose weight naturally can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it you need to err to the side of caution and permit the FDA do its job and demand some research be done so that the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on his or her medications.

Researchers discovered that participants using this drug for the year, lost excess weight within four weeks and have kept the body weight off throughout the 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, that might make them far better and safer.

Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular could be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heartbeat, and must not be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


"This is the first drug I'm alert to that targets the two appetite and reward centres inside brain," he explained.